There is considerable interest today for the reactions of anticancer metallodrugs with proteins as these interactions might feature processes that are crucial for the biodistribution, the toxicity and even the mechanism of action of this important group of anticancer agents.
Valuable structural and functional information on these adducts could be derived from several biophysical studies mainly relying on the application of X-ray diffraction and ESI MS techniques. The structural and functional information achieved on the respective metallodrug–protein adducts allowed us to identify some general trends in the reactivity of anticancer metallodrugs with protein targets.
University of Pisa, Italy - ORCID: 0000-0002-8468-4838
Titolo del libro
Proteins as possible targets for antitumor metal complexes: biophysical studies of their interactions
Autori
Chiara Gabbiani
Opera sottoposta a peer review
Numero di pagine
74
Anno di pubblicazione
2009
Copyright
© 2009 Author(s)
Licenza d'uso
Licenza dei metadati
Editore
Firenze University Press
DOI
10.36253/978-88-8453-940-3
ISBN Print
978-88-8453-939-7
eISBN (pdf)
978-88-8453-940-3
eISBN (xml)
978-88-9273-767-9
Collana
Premio Tesi di Dottorato
ISSN della collana
2612-8039
e-ISSN della collana
2612-8020