First Section: Putative CSF biomarkers of Alzheimer’s disease based on the novel concept of generic protein misfolding and proteotoxicity: the PRAMA cohort
- Liliana Napolitano
- © 2026 Author(s) |
- CC BY 4.0
- DOI: 10.36253/979-12-215-0993-9.04
This study explores novel Cereborspinal Fluid (CSF) biomarkers for Alzheimer’s Disease (AD) based on the generic failure of the proteostasis network in the PRAMA cohort. Using biophysical methods like Dynamic Light Scattering (DLS) and cellular Ca2+ influx assays, we identified large protein aggregates and proteotoxic species as key indicators of AD. These parameters effectively discriminate AD patients from non-AD controls. Combining these novel biomarkers with classical Aβ and tau markers significantly enhances diagnostic accuracy, providing a more comprehensive profile of the proteome-wide dysfunction in AD.
- Keywords:
- CSF Biomarkers,
- PRAMA Cohort,
- Protein Aggregates,
- Proteotoxicity,
- Diagnostic Accuracy.,
- ORCID: 0009-0004-3087-286X
Informazioni sul capitolo
Titolo del capitolo
First Section: Putative CSF biomarkers of Alzheimer’s disease based on the novel concept of generic protein misfolding and proteotoxicity: the PRAMA cohort
Autori
Liliana Napolitano
Lingua
Inglese
DOI
10.36253/979-12-215-0993-9.04
Opera sottoposta a peer review
Anno di pubblicazione
2026
Copyright
© 2026 Author(s)
Licenza d'uso
Licenza dei metadati
Informazioni bibliografiche
Titolo del libro
A multidisciplinary approach for the early diagnosis of Alzheimer’s disease and potential therapeutic applications
Autori
Liliana Napolitano
Opera sottoposta a peer review
Numero di pagine
184
Anno di pubblicazione
2026
Copyright
© 2026 Author(s)
Licenza d'uso
Licenza dei metadati
Editore
Firenze University Press
DOI
10.36253/979-12-215-0993-9
ISBN Print
979-12-215-0992-2
eISBN (pdf)
979-12-215-0993-9
eISBN (xml)
979-12-215-0994-6
Collana
Premio Tesi di Dottorato Città di Firenze
ISSN della collana
3103-3881
e-ISSN della collana
3103-3989