First Section: Putative CSF biomarkers of Alzheimer’s disease based on the novel concept of generic protein misfolding and proteotoxicity: the PRAMA cohort
- Liliana Napolitano
- © 2026 Author(s) |
- CC BY 4.0
- DOI: 10.36253/979-12-215-0993-9.04
This study explores novel Cereborspinal Fluid (CSF) biomarkers for Alzheimer’s Disease (AD) based on the generic failure of the proteostasis network in the PRAMA cohort. Using biophysical methods like Dynamic Light Scattering (DLS) and cellular Ca2+ influx assays, we identified large protein aggregates and proteotoxic species as key indicators of AD. These parameters effectively discriminate AD patients from non-AD controls. Combining these novel biomarkers with classical Aβ and tau markers significantly enhances diagnostic accuracy, providing a more comprehensive profile of the proteome-wide dysfunction in AD.
- Keywords:
- CSF Biomarkers,
- PRAMA Cohort,
- Protein Aggregates,
- Proteotoxicity,
- Diagnostic Accuracy.,
- ORCID: 0009-0004-3087-286X
Chapter Information
Chapter Title
First Section: Putative CSF biomarkers of Alzheimer’s disease based on the novel concept of generic protein misfolding and proteotoxicity: the PRAMA cohort
Authors
Liliana Napolitano
Language
English
DOI
10.36253/979-12-215-0993-9.04
Peer Reviewed
Publication Year
2026
Copyright Information
© 2026 Author(s)
Content License
Metadata License
Bibliographic Information
Book Title
A multidisciplinary approach for the early diagnosis of Alzheimer’s disease and potential therapeutic applications
Authors
Liliana Napolitano
Peer Reviewed
Number of Pages
184
Publication Year
2026
Copyright Information
© 2026 Author(s)
Content License
Metadata License
Publisher Name
Firenze University Press
DOI
10.36253/979-12-215-0993-9
ISBN Print
979-12-215-0992-2
eISBN (pdf)
979-12-215-0993-9
eISBN (xml)
979-12-215-0994-6
Series Title
Premio Tesi di Dottorato Città di Firenze
Series ISSN
3103-3881
Series E-ISSN
3103-3989