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Book Chapter

Restituire passi: il salvataggio d’arto

  • Walter Dorigo
  • Sara Speziali
  • Roberto Falso
  • Laura Paperetti
  • Flavia Ciavarelli
  • Carlo Pratesi
  • Raffaele Pulli

Critical limb ischemia represents one of the most complex challenges in vascular surgery. The Florentine School has made significant contributions to basic research, the development of surgical and endovascular techniques, and pharmacological and cellular therapies, promoting a multidisciplinary approach aimed at limb salvage and improved patient prognosis.

  • Keywords:
  • Critical limb ischemia,
  • Open surgery,
  • Bypass,
  • Endovascular surgery,
  • Limb salvage,
  • Medical management,
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Walter Dorigo

University of Florence, Italy - ORCID: 0000-0003-3814-5961

Sara Speziali

University of Florence, Italy

Roberto Falso

University of Florence, Italy - ORCID: 0009-0005-0173-7498

Laura Paperetti

University of Florence, Italy

Flavia Ciavarelli

University of Florence, Italy

Carlo Pratesi

University of Florence, Italy - ORCID: 0000-0003-1815-4158

Raffaele Pulli

University of Florence, Italy - ORCID: 0000-0003-1343-437X

  1. Belch, J. J. et al. 2010. “Results of the randomized, placebo-controlled clopidogrel and acetylsalicylic acid in bypass surgery for peripheral arterial disease (CASPAR) trial.” Journal of Vascular Surgery 52 (4): 825–33.
  2. Bonaca, M. P. et al. 2020. “Rivaroxaban in peripheral artery disease after revascularization.” New England Journal of Medicine 382 (21): 1994–2004.
  3. de Donato, G. et al. 2006. “The ILAILL study: iloprost as adjuvant to surgery for acute ischemia of lower limbs.” Annals of Surgery 244 (2): 185–93.
  4. de Donato, G. et al. 2007. “Acute limb ischemia in elderly patients: can iloprost be useful as an adjuvant to surgery? Results from the ILAILL study.” European Journal of Vascular and Endovascular Surgery 34 (2): 194–98.
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  6. Dorigo, W. et al. 2008. “Lower limb revascularization with a new bioactive prosthetic graft: early and late results.” Annals of Vascular Surgery 22 (1): 79–87.
  7. Dorigo, W. et al. 2011. “A multicentre comparison between autologous saphenous vein and heparin-bonded expanded polytetrafluoroethylene (ePTFE) graft in the treatment of critical limb ischemia in diabetics.” Journal of Vascular Surgery 54 (5): 1332–38.
  8. Dorigo, W. et al. 2012. “Results from an Italian multicentric registry comparing heparin-bonded ePTFE graft and autologous saphenous vein in below-knee femoro-popliteal bypasses.” Journal of Cardiovascular Surgery 53 (2): 187–94.
  9. Dorigo, W. et al. 2017. “A comparison between aortobifemoral bypass and aortoiliac kissing stents in patients with complex aortoiliac obstructive disease.” Journal of Vascular Surgery 65 (1): 99–107.
  10. Dorigo, W. et al. 2017. “A multicenter predictive score for amputation-free survival for patients operated on with a heparin-bonded ePTFE graft for critical limb ischemia.” World Journal of Surgery 41 (1): 306–13.
  11. Dorigo, W. et al. 2022. “Autologous saphenous vein and heparin-bonded expanded polytetrafluoroethylene as graft materials for below-the-knee femoro-popliteal bypass in patients with critical limb ischemia: a propensity score-matched analysis.” The Surgeon 20 (2): 85–93.
  12. Falso, R. et al. 2025. “Contemporary results of intra-arterial thrombolysis for acute and acute-on-chronic lower limb ischemia.” Annals of Vascular Surgery, in press.
  13. Govsyeyev, N. et al. 2023. “Rivaroxaban in patients with symptomatic peripheral artery disease after lower extremity bypass surgery with venous and prosthetic conduits.” Journal of Vascular Surgery 77 (4): 1107–18.
  14. Grifoni, E. et al. 2018. “On-treatment platelet reactivity is a predictor of adverse events in peripheral artery disease patients undergoing percutaneous angioplasty.” European Journal of Vascular and Endovascular Surgery 56 (4): 545–52.
  15. Groot Jebbink, E. et al. 2019. “Meta-analysis of individual patient data after kissing stent treatment for aortoiliac occlusive disease.” Journal of Endovascular Therapy 26 (1): 31–40.
  16. Liotta, F. et al. 2018. “Therapeutic efficacy of autologous non-mobilized enriched circulating endothelial progenitors in patients with critical limb ischemia: the SCELTA trial.” Circulation Journal 82 (6): 1688–98.
  17. Piffaretti, G. et al. 2018. “Results from a multicenter registry of heparin-bonded expanded polytetrafluoroethylene graft for above-the-knee femoropopliteal bypass.” Journal of Vascular Surgery 67 (5): 1463–70.
  18. Piffaretti, G. et al. 2019. “Outcomes from the multicenter Italian registry on primary endovascular treatment of aortoiliac occlusive disease.” Journal of Endovascular Therapy 26 (5): 623–32.
  19. Piffaretti, G. et al. 2019. “Prevalence and risk factors for heparin-bonded expanded polytetrafluoroethylene vascular graft infection after infrainguinal femoropopliteal bypasses.” Journal of Vascular Surgery 70 (4): 1299–307.
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  24. Pulli, R. et al. 2011. “Early and long-term comparison of endovascular treatment of iliac artery occlusions and stenosis.” Journal of Vascular Surgery 53 (1): 92–98.
  25. Pulli, R. et al. 2012. “Gender-related outcomes in the endovascular treatment of infrainguinal arterial obstructive disease.” Journal of Vascular Surgery 55 (1): 105–12.
  26. Pulli, R. et al. 2015. “Early and midterm results of kissing stent technique in the management of aortoiliac obstructive disease.” Annals of Vascular Surgery 29 (3): 543–50.
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  29. Squizzato, F. et al. 2021. “Covered versus bare metal kissing stents for reconstruction of the aortic bifurcation in the ILIACS registry.” Journal of Vascular Surgery 73 (6): 1980–90.
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  • Publication Year: 2026
  • Pages: 65-76
  • Content License: CC BY 4.0
  • © 2026 Author(s)

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  • Publication Year: 2026
  • Content License: CC BY 4.0
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Chapter Information

Chapter Title

Restituire passi: il salvataggio d’arto

Authors

Walter Dorigo, Sara Speziali, Roberto Falso, Laura Paperetti, Flavia Ciavarelli, Carlo Pratesi, Raffaele Pulli

Language

Italian

DOI

10.36253/979-12-215-0880-2.07

Peer Reviewed

Publication Year

2026

Copyright Information

© 2026 Author(s)

Content License

CC BY 4.0

Metadata License

CC0 1.0

Bibliographic Information

Book Title

La Chirurgia Vascolare dell’Ateneo Fiorentino: 50 anni di storia

Editors

Carlo Pratesi, Raffaele Pulli

Peer Reviewed

Number of Pages

104

Publication Year

2026

Copyright Information

© 2026 Author(s)

Content License

CC BY 4.0

Metadata License

CC0 1.0

Publisher Name

Firenze University Press

DOI

10.36253/979-12-215-0880-2

ISBN Print

979-12-215-0878-9

eISBN (pdf)

979-12-215-0880-2

Series Title

Dialoghi con la società

Series ISSN

2975-0210

Series E-ISSN

2975-0334

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