Introduction
- Liliana Napolitano
- © 2026 Author(s) |
- CC BY 4.0
- DOI: 10.36253/979-12-215-0993-9.02
This chapter provides an extensive review of Alzheimer’s Disease, covering its etiology, genetics, and the central role of protein misfolding and proteostasis. It details the Amyloid-β aggregation pathways and associated pathogenic mechanisms, such as mitochondrial dysfunction and oxidative stress. The discussion extends to current diagnostic landscapes, including the A/T/N classification in CSF and blood, and introduces ultrasensitive technologies like SIMOA. Finally, the chapter reviews immunotherapeutic advancements, focusing on monoclonal antibodies in clinical trials and the development of camelid-derived single-domain antibodies (nanobodies) for the targeted neutralization of toxic Aβ oligomers.
- Keywords:
- Alzheimer’s Disease,
- Protein Misfolding,
- Biomarkers,
- SIMOA,
- Immunotherapy,
- Single-domain Antibodies (Nanobodies),
- ORCID: 0009-0004-3087-286X
Chapter Information
Chapter Title
Introduction
Authors
Liliana Napolitano
Language
English
DOI
10.36253/979-12-215-0993-9.02
Peer Reviewed
Publication Year
2026
Copyright Information
© 2026 Author(s)
Content License
Metadata License
Bibliographic Information
Book Title
A multidisciplinary approach for the early diagnosis of Alzheimer’s disease and potential therapeutic applications
Authors
Liliana Napolitano
Peer Reviewed
Number of Pages
184
Publication Year
2026
Copyright Information
© 2026 Author(s)
Content License
Metadata License
Publisher Name
Firenze University Press
DOI
10.36253/979-12-215-0993-9
ISBN Print
979-12-215-0992-2
eISBN (pdf)
979-12-215-0993-9
eISBN (xml)
979-12-215-0994-6
Series Title
Premio Tesi di Dottorato Città di Firenze
Series ISSN
3103-3881
Series E-ISSN
3103-3989