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Book Chapter

Al cuore dell’innovazione: l’organo aorta

  • Sara Speziali
  • Walter Dorigo
  • Rossella Di Domenico
  • Brigida Biancofiore
  • Marco Campolmi
  • Elisa Piscitello
  • Carlo Pratesi
  • Raffaele Pulli

Abdominal aortic aneurysm represents a paradigmatic model of the evolution of vascular surgery. The Florentine School has made significant contributions to the biological, genetic, and clinical study of the disease and to the development of open and endovascular techniques, promoting a personalized, multidisciplinary approach with excellent outcomes.

  • Keywords:
  • Abdominal aortic aneurysm,
  • Open repair,
  • Endovascular repair,
  • Complex aneurysm,
  • Technology,
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Sara Speziali

University of Florence, Italy

Walter Dorigo

University of Florence, Italy - ORCID: 0000-0003-3814-5961

Rossella Di Domenico

University of Florence, Italy

Brigida Biancofiore

University of Florence, Italy

Marco Campolmi

University of Florence, Italy - ORCID: 0009-0009-0798-0471

Elisa Piscitello

University of Florence, Italy

Carlo Pratesi

University of Florence, Italy - ORCID: 0000-0003-1815-4158

Raffaele Pulli

University of Florence, Italy - ORCID: 0000-0003-1343-437X

  1. Adembri, C. et al. 2004. “Pulmonary injury follows systemic inflammatory reaction in infrarenal aortic surgery.” Critical Care Medicine 32 (5): 1170–77.
  2. Bertagna, G. et al. 2025. “Endovascular aneurysm repair with Zenith Alpha abdominal stent-graft in hostile and nonhostile aortic neck anatomies.” Annals of Vascular Surgery 116: 81–91.
  3. Brunelli, T. et al. 2000. “High prevalence of mild hyperhomocysteinemia in patients with abdominal aortic aneurysm.” Journal of Vascular Surgery 32 (3): 531–36.
  4. Di Domenico, R. et al. 2024. “The Gore Viabahn balloon-expandable stent graft as a bridging stent in complex endovascular aortic procedures at 3 years performs better in fenestrations.” Journal of Vascular Surgery 80 (6): 1650–57.
  5. Esposito, D. et al. 2022. “Stability of the aneurysmatic sac post-EVAR could no longer be a reliable criterion of healing.” Journal of Cardiovascular Surgery 63 (2): 155–59.
  6. Esposito, D. et al. 2023. “Total iodine contrast-free strategy for the endovascular management of abdominal aortic aneurysms in chronic kidney disease patients: a pilot study.” Annals of Vascular Surgery 93: 92–102.
  7. Esposito, D. et al. 2024. “Systematic review and meta-analysis of outcomes after semi-conversion with graft preservation for failed endovascular aneurysm repair.” Journal of Vascular Surgery 79 (4): 973–81.
  8. Esposito, D. et al. 2024. “Systematic review and meta-analysis of elective open conversion versus fenestrated and branched endovascular repair for previous non-infected failed endovascular aneurysm repair.” European Journal of Vascular and Endovascular Surgery 67 (3): 393–405.
  9. Esposito, D. et al. 2025. “Editor’s choice–implementation of the updated European Society for Vascular Surgery proposed endovascular aneurysm repair surveillance algorithm in a multicentre cohort with a minimum five-year follow-up adherence: further improvement of results via one-year sac dynamics.” European Journal of Vascular and Endovascular Surgery 70 (3): 307–16.
  10. Falso, R. et al. 2025. “Total iodine contrast-free protocol in complex endovascular aneurysm repair.” Journal of Endovascular Therapy, in press.
  11. Fargion, A. T. et al. 2023. “Fate of target visceral vessels in fenestrated and branched complex endovascular aortic repair.” Journal of Vascular Surgery 78 (3): 584–92.
  12. Freyrie, A. et al. 2011. “Anaconda™: the Italian Registry. Study protocol and preliminary perioperative results.” Journal of Cardiovascular Surgery 52 (5): 629–35.
  13. Freyrie, A. et al. 2014. “Proximal aortic neck angle does not affect early and late EVAR outcomes: an Anaconda™ Italian Registry analysis.” Journal of Cardiovascular Surgery 55 (5): 671–77.
  14. Gallitto, E. et al. 2021. “Preoperative and postoperative predictors of clinical outcome of fenestrated and branched endovascular repair for complex abdominal and thoracoabdominal aortic aneurysms in an Italian multicenter registry.” Journal of Vascular Surgery 74 (6): 1795–806.
  15. Gallitto, E. et al. 2022. “Fenestrated and branched endografts for post-dissection thoraco-abdominal aneurysms: results of a national multicentre study and literature review.” European Journal of Vascular and Endovascular Surgery 64 (6): 630–38.
  16. Galora, S. et al. 2015. “Association of rs1466535 LRP1 but not rs3019885 SLC30A8 and rs6674171 TDRD10 gene polymorphisms with abdominal aortic aneurysm in Italian patients.” Journal of Vascular Surgery 61 (3): 787–92.
  17. Giacomelli, E. et al. 2020. “Acute thrombosis of an aortic prosthetic graft in a patient with severe COVID-19-related pneumonia.” Annals of Vascular Surgery 66: 8–10.
  18. Giacomelli, E. et al. 2021. “A pilot study of the enhanced recovery after surgery protocol in aortic surgery.” Journal of Vascular Surgery 74 (1): 90–96.
  19. Giacomelli, E. et al. 2024. “The use of pressure recording analytical method in patients undergoing endovascular repair for abdominal aortic aneurysm: the impact on clinical decisions for the appropriate postoperative setting and cost-effective analysis.” Acta Medica Academica 53 (1): 10–23.
  20. Giusti, B. et al. 2009. “Gene expression profiling of peripheral blood in patients with abdominal aortic aneurysm.” European Journal of Vascular and Endovascular Surgery 38 (1): 104–12.
  21. Isernia, G. et al. 2024. “Sex influence on fenestrated and branched endovascular aortic aneurysm repair: outcomes from a national multicenter registry.” Journal of Endovascular Therapy 31 (4): 697–705.
  22. Jones, G. T. et al. 2017. “Meta-analysis of genome-wide association studies for abdominal aortic aneurysm identifies four new disease-specific risk loci.” Circulation Research 120 (2): 341–53.
  23. Lo Sapio, P. et al. 2014. “Impact of two different cardiac work-up strategies in patients undergoing abdominal aortic aneurysm repair.” International Journal of Cardiology 175 (1): e1–e3.
  24. Marone, E. M. et al. 2024. “Endovascular aortic repair with the E-Tegra device: preliminary outcomes from a multicenter national registry.” Journal of Endovascular Therapy.
  25. Masciello, F. et al. 2020. “A propensity score-matched comparison of two commercially available iliac branch devices in patients with similar clinical and anatomic preoperative features.” Journal of Vascular Surgery 71 (4): 1207–14.
  26. Modesti, P. A. et al. 2009. “Response of serum proteome in patients undergoing infrarenal aortic aneurysm repair.” Anesthesiology 111 (4): 844–54.
  27. O’Donnell, T. F. X. et al. 2020. “Female sex is associated with comparable 5-year outcomes after contemporary endovascular aneurysm repair despite more challenging anatomy.” Journal of Vascular Surgery 71 (4): 1179–89.
  28. Piffaretti, G. et al. 2025. “Acute kidney injury and aorta-related mortality during open surgery of the abdominal aorta with suprarenal clamping using different renal protection strategies.” European Journal of Cardio-Thoracic Surgery 67 (5): ezaf159.
  29. Pini, R. et al. 2020. “The Italian multicentre registry of fenestrated Anaconda™ endografts for complex abdominal aortic aneurysms repair.” European Journal of Vascular and Endovascular Surgery 60 (2): 181–91.
  30. Pratesi, C. et al. 2006. “Acute traumatic rupture of the descending thoracic aorta: endovascular treatment.” American Journal of Surgery 192 (3): 291–95.
  31. Pratesi, C. et al. 2014. “Italian Excluder Registry and results of Gore Excluder endograft for the treatment of elective infrarenal abdominal aortic aneurysms.” Journal of Vascular Surgery 59 (1): 52–57.
  32. Pratesi, C. et al. 2022. “Guidelines on the management of abdominal aortic aneurysms: updates from the Italian Society of Vascular and Endovascular Surgery (SICVE).” Journal of Cardiovascular Surgery 63 (3): 328–52.
  33. Pratesi, G. et al. 2013. “Endovascular treatment of aorto-iliac aneurysms: four-year results of iliac branch endograft.” European Journal of Vascular and Endovascular Surgery 45 (6): 607–9.
  34. Pratesi, G. et al. 2015. “Italian Percutaneous EVAR (IPER) Registry: outcomes of 2381 percutaneous femoral access sites’ closure for aortic stent-graft.” Journal of Cardiovascular Surgery 56 (6): 889–98.
  35. Pratesi, G. et al. 2018. “Ten-year outcome analysis of the Italian Excluder Registry with the Gore Excluder endograft for infrarenal abdominal aortic aneurysms.” Journal of Vascular Surgery 67 (3): 740–46.
  36. Saracini, C. et al. 2012. “Polymorphisms of genes involved in extracellular matrix remodeling and abdominal aortic aneurysm.” Journal of Vascular Surgery 55 (1): 171–79.
  37. Scheinert, D. et al. 2013. “First-in-human study of the INCRAFT endograft in patients with infrarenal abdominal aortic aneurysms in the INNOVATION trial.” Journal of Vascular Surgery 57 (4): 906–14.
  38. Sofi, F. et al. 2005. “High levels of homocysteine, lipoprotein (a) and plasminogen activator inhibitor-1 are present in patients with abdominal aortic aneurysm.” Thrombosis and Haemostasis 94 (5): 1094–98.
  39. Spanos, K. et al. 2020. “Iliac branch devices with standard vs fenestrated/branched stent-grafts: does aneurysm complexity produce worse outcomes? Insights from the pELVIS registry.” Journal of Endovascular Therapy 27 (6): 910–16.
  40. Stokmans, R. A. et al. 2012. “Early results from the ENGAGE registry: real-world performance of the Endurant stent graft for endovascular AAA repair in 1262 patients.” European Journal of Vascular and Endovascular Surgery 44 (4): 369–75.
  41. Torsello, G. et al. 2010. “Endovascular aortic aneurysm repair with the Endurant stent-graft: early and 1-year results from a European multicenter experience.” Journal of Vascular and Interventional Radiology 21 (1): 73–80.
  42. Troisi, N. et al. 2010. “Hybrid treatment of aortic arch aneurysms.” Journal of Cardiovascular Surgery 51 (3): 377–82.
  43. Troisi, N. et al. 2010. “Preoperative cardiac assessment in patients undergoing aortic surgery: analysis of factors affecting the cardiac outcomes.” Annals of Vascular Surgery 24 (6): 733–40.
  44. Verhagen, H. J. M. et al. 2025. “The ENGAGE registry ten-year outcomes with the Endurant stent graft system for endovascular abdominal aortic aneurysm repair.” European Journal of Vascular and Endovascular Surgery, in press.
  45. Villa, F. et al. 2025. “Results of the Italian Collaborators for EVAR Registry on acute kidney injury after elective endovascular aortic repair of infrarenal abdominal aortic aneurysm.” Journal of Endovascular Therapy 32 (6): 2115–26.
  46. Zacà, S. et al. 2024. “Cardiac risk after elective endovascular repair for infrarenal abdominal aortic aneurysm: results from the Italian Collaborators for EVAR multicenter registry.” Journal of Vascular Surgery 79 (2): 260–68.
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  • Publication Year: 2026
  • Pages: 49-63
  • Content License: CC BY 4.0
  • © 2026 Author(s)

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  • Publication Year: 2026
  • Content License: CC BY 4.0
  • © 2026 Author(s)

Chapter Information

Chapter Title

Al cuore dell’innovazione: l’organo aorta

Authors

Sara Speziali, Walter Dorigo, Rossella Di Domenico, Brigida Biancofiore, Marco Campolmi, Elisa Piscitello, Carlo Pratesi, Raffaele Pulli

Language

Italian

DOI

10.36253/979-12-215-0880-2.06

Peer Reviewed

Publication Year

2026

Copyright Information

© 2026 Author(s)

Content License

CC BY 4.0

Metadata License

CC0 1.0

Bibliographic Information

Book Title

La Chirurgia Vascolare dell’Ateneo Fiorentino: 50 anni di storia

Editors

Carlo Pratesi, Raffaele Pulli

Peer Reviewed

Number of Pages

104

Publication Year

2026

Copyright Information

© 2026 Author(s)

Content License

CC BY 4.0

Metadata License

CC0 1.0

Publisher Name

Firenze University Press

DOI

10.36253/979-12-215-0880-2

ISBN Print

979-12-215-0878-9

eISBN (pdf)

979-12-215-0880-2

Series Title

Dialoghi con la società

Series ISSN

2975-0210

Series E-ISSN

2975-0334

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